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KMID : 0644320060110010055
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Journal of Korean Oriental Oncology
2006 Volume.11 No. 1 p.55 ~ p.63
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Angiogenic inhibitory effect of Zingiberis Rhizoma Angiogenic inhibitory effect of Zingiberis Rhizoma
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Nam Sang-Choon
Kang Hee
Shim Bum-Sang
Kim Sung-Hoon
Choi Seung-Hun
Ahn Kyoo-Seok
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Abstract
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This study was conducted to investigate angiogenic inhibitory effect of Zingiberis Rhizoma methanol extract using ECV-304 cells and HT1080 fibrosarcoma cells. The viability of ECV-304 was 30% at 50 ug/mll of Zingiberis extract and that of HT1080 was 30% at 100 ug/ml. Using the BrdU incorporation assay, Zingiberis inhibited the DNA synthesis of ECV-304 and HT1080 by 70% and 50 % at 200 ug/ml. In tube formation assay, at 10 ug/ml of Zingiberis, tube network began to degrade and at higher doses, it was completely destroyed. Zymography demonstrated that Zingiberis extract decreased MMP-9 at 10 and higher doses remarkably inhibited the expression of MMP-9. These data indicate that Zingiberis Rhizoma has angiogenic inhibitory effects and shows the possibility of future anti-metastatic drug.
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KEYWORD
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ZingiberisRhizoma, angiogenesis, ECV304, HT1080
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